Among a litany of malignancies affecting the female reproductive tract, that of the ovary is the
most frequently fatal. Moreover, while the steady pace of scientific discovery has fuelled …

The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …

T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic
agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the …

Ovarian cancer (OC) represents the most dismal gynecological cancer. Pathobiology is
poorly understood, mainly due to lack of appropriate study models. Organoids, defined as …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Metastasis is a complex multistep process that involves critical interactions between cancer
cells and a variety of stromal components in the tumor microenvironment, which profoundly …

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high
ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Epithelial ovarian cancer (EOC) cells metastasize within the peritoneal cavity and directly
encounter human peritoneal mesothelial cells (HPMC) as the initial step of metastasis. The …