The MR1/MAIT cell axis in CNS diseases

R Shrinivasan, SK Wyatt-Johnson… - Brain, Behavior, and …, 2023 - Elsevier
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that
can be found throughout the body, predominantly in mucosal sites, the lungs and in the …

[HTML][HTML] An Overview of Multiple Sclerosis In Vitro Models

J Czpakowska, M Kałuża, P Szpakowski… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) still poses a challenge in terms of complex etiology, not fully effective
methods of treatment, and lack of healing agents. This neurodegenerative condition …

[HTML][HTML] Auranofin Modulates Thioredoxin Reductase/Nrf2 Signaling in Peripheral Immune Cells and the CNS in a Mouse Model of Relapsing–Remitting EAE

LA Al-Kharashi, NO Al-Harbi, SF Ahmad, SM Attia… - Biomedicines, 2023 - mdpi.com
Multiple sclerosis (MS) is one of the most prevalent chronic inflammatory autoimmune
diseases. It causes the demyelination of neurons and the subsequent degeneration of the …

Novel liposomal glatiramer acetate: Preparation and immunomodulatory evaluation in murine model of multiple sclerosis

N Rahiman, P Zamani, L Arabi, SH Alavizadeh… - International Journal of …, 2023 - Elsevier
The frequent administration rate required for Glatiramer acetate (GA), a first-line therapy for
Multiple sclerosis (MS), poses patient compliance issues. Only a small portion of the …

Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis

S Barriola, LM Delgado-García, P Cartas-Cejudo… - Neuroscience, 2023 - Elsevier
Multiple sclerosis (MS) is a complex autoimmune and neurodegenerative disorder that
affects the central nervous system (CNS). It is characterized by a heterogeneous disease …

Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE

M Quan, H Zhang, X Han, Y Ba, X Cui, Y Bi… - Neurology …, 2024 - neurology.org
Background and Objectives Neutrophils, underestimated in multiple sclerosis (MS), are
gaining increased attention for their significant functions in patients with MS and the …

[HTML][HTML] Integration of iPSC-Derived Microglia into Brain Organoids for Neurological Research

MA Mrza, J He, Y Wang - International Journal of Molecular Sciences, 2024 - mdpi.com
The advent of Induced Pluripotent Stem Cells (iPSCs) has revolutionized neuroscience
research. This groundbreaking innovation has facilitated the development of three …

A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4

Z Song, J Li, Y He, X Wang, J Tian, Y Wu - International …, 2024 - Elsevier
Neuroinflammation and neurodegeneration are hallmarks of multiple sclerosis (MS).
Bromodomain-containing protein 4 (BRD4), a bromodomain and extra-terminal domain …

Adipose‐derived mesenchymal stem cells ameliorates experimental autoimmune encephalomyelitis via modulation of Th1/Th17 and expansion of Th2/Treg …

S Zargarani, MJ Tavaf… - Cell Biology …, 2024 - Wiley Online Library
The most common central nervous system (CNS) inflammatory disease is multiple sclerosis
(MS), modeled using experimental autoimmune encephalomyelitis (EAE). Mesenchymal …

The Immune System in Neurological Diseases: What Innate-like T Cells have to Say

SK Wyatt-Johnson, R Afify, RR Brutkiewicz - Journal of Allergy and Clinical …, 2024 - Elsevier
The immune system classically consists of two lines of defense: innate and adaptive, both of
which interact with one another effectively to protect us against any pathogenic threats …