RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …

Abstract Background N‐acetyltransferase 10 (NAT10) is the only enzyme known to mediate
the N4‐acetylcytidine (ac4C) modification of mRNA and is crucial for mRNA stability and …

Abstract Background N4-acetylcytidine (ac4C) as a significant RNA modification has been
reported to maintain the stability of mRNA and to regulate the translation process. However …

Anti‐angiogenic therapy has long been considered a promising strategy for solid cancers.
Intrinsic resistance to hypoxia is a major cause for the failure of anti‐angiogenic therapy, but …

Background N‐4 cytidine acetylation (ac4C) is an epitranscriptomics modification catalyzed
by N‐acetyltransferase 10 (NAT10); important for cellular mRNA stability, rRNA biogenesis …

The loss of bone and destruction of bone microstructure due to aging in senile osteoporosis
(SOP) significantly impair the health and quality of life of the elderly. The pathogenesis of …

RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …

Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …