The dynamics of CNS function rely upon omnidirectional communication among CNS cell
types. Extracellular vesicles (EVs) have emerged as key mediators of this communication …

Simple Summary Exosomes (or extracellular vesicles) are known to mediate intercellular
communication and to transmit molecular signals between cells. Molecules carried by …

Astroglia play active and diverse roles in modulating neuronal/synaptic functions in the CNS.
How these astroglial functions are regulated, especially by neuronal signals, remains largely …

Amyotrophic lateral sclerosis (ALS) is described as a fatal and rapidly progressive
neurodegenerative disorder caused by the degeneration of upper motor neurons in the …

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurological disease affecting
both upper and lower motor neurons. In the United States alone, there are 16,000–20,000 …

We meta-analyze amyotrophic lateral sclerosis (ALS) genome-wide association study
(GWAS) data of European and Chinese populations (84,694 individuals). We find an …

Abstract TAR DNA binding protein 43 (TDP-43) is closely related to the pathogenesis of
amyotrophic lateral sclerosis (ALS) and translocates to stress granules (SGs). The role of …

A lack of stratification methods in patients with amyotrophic lateral sclerosis (ALS) is likely
implicated in therapeutic failures. Regional diversities and pathophysiological abnormalities …

The clinical manifestations of amyotrophic lateral sclerosis (ALS) are variable in terms of age
at disease onset, site of onset, progression of symptoms, motor neuron involvement, and the …

Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …