Donanemab for Alzheimer disease—who benefits and who is harmed?

JJ Manly, KD Deters - JAMA, 2023 - jamanetwork.com
Availability of safe and effective treatmentsfor Alzheimer disease is an urgent challenge
given the global shift toward an older population and increased risk of mild cognitive …

Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment

DC Javitt, A Martinez, P Sehatpour… - Alzheimer's Research & …, 2023 - Springer
Background Amyloid deposition is a primary predictor of Alzheimer's disease (AD) and
related neurodegenerative disorders. Retinal changes involving the structure and function of …

Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome

P Lao, N Edwards, L Flores-Aguilar, M Alshikho… - Scientific Reports, 2024 - nature.com
Adults with Down syndrome have a genetic form of Alzheimer's disease (AD) and evidence
of cerebrovascular disease across the AD continuum, despite few systemic vascular risk …

Cerebrovascular miRNAs track early development of Alzheimer's disease and target molecular markers of angiogenesis and blood flow regulation

PP Chum, MA Bishara, SR Solis… - Journal of Alzheimer's …, 2024 - content.iospress.com
Background: Alzheimer's disease (AD) is associated with impaired cerebral circulation
which underscores diminished delivery of blood oxygen and nutrients to and throughout the …

[HTML][HTML] Associations of Cerebrovascular Disease and Alzheimer's Disease Pathology with Cognitive Decline: Analysis of the National Alzheimer's Coordinating …

A Chatterjee, S Lee, V Diaz, R Saloner… - Neurobiology of …, 2024 - Elsevier
Cerebrovascular disease (CVD) and Alzheimer's disease (AD) often co-occur and may
impact specific cognitive domains. This study's goal was to determine effects of CVD and AD …

The heritability of cerebral amyloid in older people and its relationship to vascular risk factors, cerebral small vessel disease and cognition

R Koncz - 2023 - unsworks.unsw.edu.au
Abnormal β-amyloid (Aβ) plaque accumulation, a hallmark pathological feature of
Alzheimer's disease (AD), commonly co-occurs with cerebral small vessel disease (SVD) …