Sequence divergence of orthologous proteins enables adaptation to a plethora of
environmental stresses and promotes evolution of novel functions. As one of the most …

The question of how sequence encodes proteins' function is essential to understand
molecular evolution but still remains elusive. Droplet-based microfluidics allows to use micro …

Novel protein sequences arise through mutation. These mutations may be deleterious,
beneficial, or neutral; the effect of a mutation on an organism's evolutionary fitness is …

Abstract Theory of evolution provides a simple, flexible, and elegant framework to study and
explain life around us. Population genetics is a mathematical wing of evolutionary theory …

Understanding how each residue position contributes to protein function has been a
longstanding goal in protein science. Substitution studies have historically focused on …

The divergence in catalytic actions of N-acetyl neuraminic lyase (NAL) superfamily proteins,
all of which have pyruvate as a substrate, suggests common ancestry. Lack of catalytic triad …

Protein sequences are constrained by complex interactions between the residues that
compose them, and models that can capture genetic variation are powerful tools in …

Integrins have the ability to impact major aspects of epithelial biology including adhesion,
migration, invasion, signaling and differentiation, as well as the formation and progression of …