[HTML][HTML] Network pharmacology approach for medicinal plants: review and assessment
Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …
[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy
FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …
development have led to a growing interest in repurposing “old” drugs to treat both common …
Artificial intelligence, machine learning, and drug repurposing in cancer
Z Tanoli, M Vähä-Koskela… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction: Drug repurposing provides a cost-effective strategy to re-use approved drugs
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
[HTML][HTML] Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
JA Malik, S Ahmed, B Jan, O Bender… - Biomedicine & …, 2022 - Elsevier
Breast cancer (BC) is mostly observed in women and is responsible for huge mortality in
women subjects globally. Due to the continued development of drug resistance and other …
women subjects globally. Due to the continued development of drug resistance and other …
[HTML][HTML] Repurposing antifungal drugs for cancer therapy
N Weng, Z Zhang, Y Tan, X Zhang, X Wei… - Journal of Advanced …, 2023 - Elsevier
Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …
attention in both preclinical and clinical research due to specific advantages, such as safety …
[HTML][HTML] The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via …
F Luo, H Li, W Ma, J Cao, Q Chen, F Lu, M Qiu… - Cellular & Molecular …, 2024 - nature.com
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …
[HTML][HTML] Repurposing of antimicrobial agents for cancer therapy: what do we know?
C Pfab, L Schnobrich, S Eldnasoury, A Gessner… - Cancers, 2021 - mdpi.com
Simple Summary Despite the leaps and bounds in the prevention and treatment of cancer, it
remains the second leading cause of death worldwide. A significant hurdle during cancer …
remains the second leading cause of death worldwide. A significant hurdle during cancer …
[HTML][HTML] Pathway-based drug-repurposing schemes in cancer: the role of translational bioinformatics
E Hernández-Lemus, M Martínez-García - Frontiers in Oncology, 2021 - frontiersin.org
Cancer is a set of complex pathologies that has been recognized as a major public health
problem worldwide for decades. A myriad of therapeutic strategies is indeed available …
problem worldwide for decades. A myriad of therapeutic strategies is indeed available …
Drug repurposing: A strategy for discovering inhibitors against emerging viral infections
IJ dos Santos Nascimento… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Viral diseases are responsible for several deaths around the world. Over the
past few years, the world has seen several outbreaks caused by viral diseases that, for a …
past few years, the world has seen several outbreaks caused by viral diseases that, for a …