Drug delivery systems for CRISPR-based genome editors
V Madigan, F Zhang, JE Dahlman - Nature Reviews Drug Discovery, 2023 - nature.com
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …
drug candidate, holding great potential to revolutionize the way we approach medicine. The …
Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination
An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
invasive and lung-targeted delivery for a host of pulmonary diseases. Development of lung …
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
SJ Shepherd, X Han, AJ Mukalel… - Proceedings of the …, 2023 - National Acad Sciences
Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …
Combinatorial development of nebulized mRNA delivery formulations for the lungs
Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However,
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …
nebulized mRNA lipid nanoparticles (LNPs) face several unique challenges including …
Iterative design of ionizable lipids for intramuscular mRNA delivery
G Tilstra, J Couture-Senécal, YMA Lau… - Journal of the …, 2023 - ACS Publications
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and
have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines …
have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines …
Recent advances in nanoparticulate RNA delivery systems
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation
Ionisable amino‐lipid is a key component in lipid nanoparticles (LNPs), which plays a crucial
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
role in the encapsulation of RNA molecules, allowing efficient cellular uptake and then …
The immunostimulatory nature of mRNA lipid nanoparticles
Abstract mRNA-Lipid nanoparticles (LNPs) are at the forefront of global medical research.
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
With the development of mRNA-LNP vaccines to combat the COVID-19 pandemic, the …
[HTML][HTML] Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues
Lipid nanoparticles (LNPs) for delivery of mRNA usually contain ionizable lipid/helper
lipid/cholesterol/PEG-lipid in molar ratios of 50: 10: 38.5: 1.5, respectively. These LNPs are …
lipid/cholesterol/PEG-lipid in molar ratios of 50: 10: 38.5: 1.5, respectively. These LNPs are …