Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Tumour formation involves the co-evolution of neoplastic cells together with extracellular
matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …

Poorly organized tumour vasculature often results in areas of limited nutrient supply and
hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient …

The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-
associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

In the last decades cancer has been considered as an epigenetic dysfunction, given the
profound role of diet and lifestyle in cancer prevention and the determination of cancer risk …

Background: Tumor initiation, growth and relapse after therapy are thought to be driven by a
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …

Colorectal cancer remains one of the most common and lethal malignancies worldwide
despite the use of various therapeutic strategies. A better understanding of the mechanisms …