[HTML][HTML] Clonal heterogeneity and tumor evolution: past, present, and the future
N McGranahan, C Swanton - Cell, 2017 - cell.com
Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …
medicine. Here, we review data and technologies that have revealed intra-tumor …
Influence of tumour micro-environment heterogeneity on therapeutic response
MR Junttila, FJ De Sauvage - Nature, 2013 - nature.com
Tumour formation involves the co-evolution of neoplastic cells together with extracellular
matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual …
matrix, tumour vasculature and immune cells. Successful outgrowth of tumours and eventual …
Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
SR McKeown - The British journal of radiology, 2014 - academic.oup.com
Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …
as it compromises treatment and drives malignant progression. This review seeks to clarify …
Concise review: cancer cells, cancer stem cells, and mesenchymal stem cells: influence in cancer development
F Papaccio, F Paino, T Regad… - Stem cells …, 2017 - academic.oup.com
Tumors are composed of different types of cancer cells that contribute to tumor
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …
heterogeneity. Among these populations of cells, cancer stem cells (CSCs) play an …
Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation
M Pan, MA Reid, XH Lowman, RP Kulkarni… - Nature cell …, 2016 - nature.com
Poorly organized tumour vasculature often results in areas of limited nutrient supply and
hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient …
hypoxia. Despite our understanding of solid tumour responses to hypoxia, how nutrient …
[HTML][HTML] Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment
The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-
associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate …
associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate …
[HTML][HTML] Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
SA Eccles, EO Aboagye, S Ali, AS Anderson… - Breast Cancer …, 2013 - Springer
Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
This gap analysis has reviewed and critically assessed enduring issues and new challenges …
The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment
F Pistollato, F Giampieri, M Battino - Food and chemical toxicology, 2015 - Elsevier
In the last decades cancer has been considered as an epigenetic dysfunction, given the
profound role of diet and lifestyle in cancer prevention and the determination of cancer risk …
profound role of diet and lifestyle in cancer prevention and the determination of cancer risk …
Hypoxia as a biomarker for radioresistant cancer stem cells
C Peitzsch, R Perrin, RP Hill… - International journal of …, 2014 - Taylor & Francis
Background: Tumor initiation, growth and relapse after therapy are thought to be driven by a
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …
population of cells with stem cell characteristics, named cancer stem cells (CSC). The …
[HTML][HTML] Cancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectives
C Fanali, D Lucchetti, M Farina, M Corbi… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer remains one of the most common and lethal malignancies worldwide
despite the use of various therapeutic strategies. A better understanding of the mechanisms …
despite the use of various therapeutic strategies. A better understanding of the mechanisms …