Aberrant MET signaling can drive tumorigenesis in several cancer types through a variety of
molecular mechanisms including MET gene amplification, mutation, rearrangement, and …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Gliomas are the most common and malignant intracranial tumors in adults. Recent studies
have revealed the significance of functional genomics for glioma pathophysiological studies …

To follow the revision of the fourth edition of WHO classification and the recent progress on
the management of diffuse gliomas, the joint guideline committee of Chinese Glioma …

Preoperative MRI is one of the most important clinical results for the diagnosis and treatment
of glioma patients. The objective of this study was to construct a stable and validatable …

Background The prognosis for diffuse gliomas is very poor and the mechanism underlying
their malignant progression remains unclear. Here, we aimed to elucidate the role and …

The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear,. Here we analysed temporally separated DNA-sequencing …

Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …

Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity.
Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods …

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an extremely low
survival rate. New and effective approaches for treatment are therefore urgently needed …