The classic definition of precocious sexual maturation is the development of secondary
sexual characteristics before 8 years of age in girls and before 9 years of age in boys. It is …

Abstract Fibrous Dysplasia/McCune Albright syndrome (FD/MAS) represents a wide
spectrum of diseases due to somatic gain-of-function mutations of the GNAS gene. The …

Objective: To develop evidence-based recommendations for safe, effective, and appropriate
thyroidectomy. Background: Surgical management of thyroid disease has evolved …

Abstract Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disorder of
striking complexity. It arises from somatic, gain-of-function mutations in GNAS, leading to …

Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating
mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and …

Fibrous dysplasia (FD) is an uncommon and debilitating skeletal disorder resulting in
fractures, deformity, functional impairment, and pain. It arises from post-zygotic somatic …

McCune-Albright syndrome (MAS) is a rare, mosaic disorder presenting along a broad
clinical spectrum. Disease arises from somatic-activating GNAS mutations, leading to …

Fibrous dysplasia is an uncommon mosaic disorder in which bone is replaced by structurally
unsound fibro-osseous tissue. It is caused by the sporadic post-zygotic activating mutations …

Fibrous dysplasia (FD) is a mosaic disease in which bone is replaced with fibro‐osseous
tissue. Lesions expand during childhood, reaching final burden by age 15 years. In vitro …

Phosphate metabolism is an evolving area of basic and clinical research. In the past 15
years, knowledge on disturbances of phosphate homoeostasis has expanded, as has the …