Association of cannabis potency with mental ill health and addiction: a systematic review

K Petrilli, S Ofori, L Hines, G Taylor, S Adams… - The Lancet …, 2022 - thelancet.com
Cannabis potency, defined as the concentration of Δ 9-tetrahydrocannabinol (THC), has
increased internationally, which could increase the risk of adverse health outcomes for …

Diversity of molecular targets and signaling pathways for CBD

DL de Almeida, LA Devi - Pharmacology research & …, 2020 - Wiley Online Library
Cannabidiol (CBD) is the second most abundant component of the Cannabis plant and is
known to have effects distinct from Δ9‐tetrahydrocannabinol (THC). Many studies that …

Changes in delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta‐analysis

TP Freeman, S Craft, J Wilson, S Stylianou… - …, 2021 - Wiley Online Library
Background and aims Cannabis products with high delta‐9‐tetrahydrocannabinol (THC)
concentrations carry an increased risk of addiction and mental health disorders, while it has …

Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals

HPV Rupasinghe, A Davis, SK Kumar, B Murray… - Molecules, 2020 - mdpi.com
Industrial hemp (Cannabis sativa L., Cannabaceae) is an ancient cultivated plant originating
from Central Asia and historically has been a multi-use crop valued for its fiber, food, and …

[HTML][HTML] Lower-Risk Cannabis Use Guidelines (LRCUG) for reducing health harms from non-medical cannabis use: A comprehensive evidence and recommendations …

B Fischer, T Robinson, C Bullen, V Curran… - International Journal of …, 2022 - Elsevier
Background Cannabis use is common, especially among young people, and is associated
with risks for various health harms. Some jurisdictions have recently moved to …

Effect of cannabidiol and Δ9-tetrahydrocannabinol on driving performance: a randomized clinical trial

TR Arkell, F Vinckenbosch, RC Kevin, EL Theunissen… - Jama, 2020 - jamanetwork.com
Importance Cannabis use has been associated with increased crash risk, but the effect of
cannabidiol (CBD) on driving is unclear. Objective To determine the driving impairment …

Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial

TP Freeman, C Hindocha, G Baio… - The Lancet …, 2020 - thelancet.com
Background A substantial and unmet clinical need exists for pharmacological treatment of
cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which …

'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration

TP Freeman, V Lorenzetti - Addiction, 2020 - Wiley Online Library
Abstract Background and Aims Cannabis products are becoming increasingly diverse, and
vary considerably in concentrations of∆ 9‐tetrahydrocannabinol (THC) and cannabidiol …

Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol

P Alves, C Amaral, N Teixeira… - Pharmacological …, 2020 - Elsevier
Cannabis is the most used illicit drug worldwide and its medicinal use is under discussion,
being regulated in several countries. However, the psychotropic effects of Δ 9 …

Endocannabinoids, cannabinoids and the regulation of anxiety

GN Petrie, AS Nastase, RJ Aukema, MN Hill - Neuropharmacology, 2021 - Elsevier
Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …