Cannabinoids, blood–brain barrier, and brain disposition

F Calapai, L Cardia, EE Sorbara, M Navarra… - Pharmaceutics, 2020 - mdpi.com
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and
cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory …

Public health monitoring of cannabis use in Europe: prevalence of use, cannabis potency, and treatment rates

J Manthey, TP Freeman, C Kilian… - The Lancet Regional …, 2021 - thelancet.com
Background Cannabis is one of the most widely used substances worldwide. Heavy use is
associated with an increased risk of cannabis use disorders, psychotic disorders, acute …

Role of cannabidiol in the therapeutic intervention for substance use disorders

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation

HJ Cindy, HPV Rupasinghe - Research in veterinary science, 2021 - Elsevier
Recent advances in cannabidiol (CBD) use in canines and felines for anxiety management,
pain management, and anti-inflammatory effects were reviewed using a literature search …

Exploring the use of cannabis as a substitute for prescription drugs in a convenience sample

SL Kvamme, MM Pedersen, K Rømer Thomsen… - Harm reduction …, 2021 - Springer
Background The use of cannabis as medicine (CaM) both prescribed and non-prescribed
has increased markedly in the last decade, mirrored in a global shift in cannabis policy …

A scoping review of the use of cannabidiol in psychiatric disorders

AE Kirkland, MC Fadus, SA Gruber, KM Gray… - Psychiatry …, 2022 - Elsevier
Cannabidiol (CBD) has become a fast-growing avenue for research in psychiatry, and
clinicians are challenged with understanding the implications of CBD for treating mental …

Clinical outcome data of anxiety patients treated with cannabis-based medicinal products in the United Kingdom: a cohort study from the UK Medical Cannabis …

R Rifkin-Zybutz, S Erridge, C Holvey, R Coomber… - …, 2023 - Springer
Rationale Cannabis-based medicinal products (CBMPs) have been identified as novel
therapeutics for generalised anxiety disorder (GAD) based on pre-clinical models; however …

Cannabidiol and substance use disorder: Dream or reality

S Karimi-Haghighi, Y Razavi, D Iezzi, AF Scheyer… - …, 2022 - Elsevier
Background Cannabidiol (CBD) is one of the major constituents of Cannabis sativa L. that
lacks psychotomimetic and rewarding properties and inhibits the rewarding and reinforcing …

Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 …

SD Lichenstein, N Manco, LM Cope, L Egbo… - …, 2022 - nature.com
Cannabis use peaks in adolescence, and adolescents may be more vulnerable to the neural
effects of cannabis and cannabis-related harms due to ongoing brain development during …

The acute effects of cannabis with and without cannabidiol in adults and adolescents: a randomised, double‐blind, placebo‐controlled, crossover experiment

W Lawn, K Trinci, C Mokrysz, A Borissova, S Ofori… - …, 2023 - Wiley Online Library
Abstract Background and Aims Long‐term harms of cannabis may be exacerbated in
adolescence, but little is known about the acute effects of cannabis in adolescents. We …