Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Recruitment and retention of leukocytes at a site of blood vessel growth are crucial for
proper angiogenesis and subsequent tissue perfusion. Although critical for many aspects of …

White and brown adipose tissues are hypervascularized and the adipose vasculature
displays phenotypic and functional plasticity to coordinate with metabolic demands of …

Context: Insulin resistance can be compensated by increased functional pancreatic β-cell
mass; otherwise, diabetes ensues. Such compensation depends not only on environmental …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Blood vessels form an important interface between the environment and the organism by
carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …