In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have
been recognized as potential targets for molecular therapy. However, there remain cases …

Chromothripsis, a type of complex chromosomal rearrangement originally known as
chromoanagenesis, has been a subject of extensive investigation due to its potential role in …

Background As a newly identified subtype of HER2-negative tumors associated with a less
favorable prognosis, it remains crucial to evaluate potential prognostic and predictive …

Background Due to its high incidence and elevated mortality, hepatocellular carcinoma
(HCC) has emerged as a formidable global healthcare challenge. The intricate interplay …

Background The development of endometrial cancer (EC) is closely related to the abnormal
activation of the estrogen signaling pathway. Effective diagnostic markers are important for …

Simple Summary Copy number abnormalities (CNAs) are frequent in neuroblastoma and
used to determine treatments. Little is known about the role of structural variants (SVs) in …

Obesity is a public health concern resulting in a variety of health complications, including
heart disease and insulin resistance. Estrogens have been associated with a reduced risk of …

Pathogenic germline TP53 alterations cause Li-Fraumeni Syndrome (LFS), and breast
cancer is the most common cancer in LFS females. We performed first of its kind multimodal …

Physiological double-stranded breaks (DSBs) are a major source of genomic instability.
Here, we present a protocol for mapping physiological DSBs by in-suspension break …

Oncogene amplification is a major driver of cancer pathogenesis. Breakage fusion bridge
(BFB) cycles, like extrachromosomal DNA (ecDNA), can lead to high copy numbers of …