Highlights•Changes in the microenvironment (TME) promote drug resistance.•Cellular
composition, biochemical and-biophysical parameters create tissue-specific TME.•Targeting …

Abstract Background Approximately 20–50% of patients presenting with localized colorectal
cancer progress to stage IV metastatic disease (mCRC) following initial treatment and this is …

Scope Epidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is
correlated with high consumption of fruits and vegetables, which are major sources of fiber …

Background: Although biological resources are essential for basic and preclinical research
in the oncological field, those of sarcoma are not sufficient for rapid development of the …

Cancer treatment is gradually evolving from the classical use of nonspecific cytotoxic drugs
targeting generic mechanisms of cell growth and proliferation. Instead, new “patient‐specific …

Simple Summary Genome-wide DNA methylation is a regulatory mechanism that is
frequently altered in human cancers. Remarkably, these epigenetic marks on DNA are …

Purpose: To investigate the antitumor activity of a mitochondrial-localized HSP90 inhibitor,
Gamitrinib, in multiple glioma models, and to elucidate the antitumor mechanisms of …

Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …

Delineating the molecular and morphological changes that cancer cells undergo in
response to extracellular stimuli is crucial for identifying factors that promote tumor …

Tumor immunotherapy is rapidly evolving as one of the major pillars of cancer treatment.
Cell-based immunotherapies, which utilize patient's own immune cells to eliminate cancer …