Tumor immunotherapy is rapidly evolving as one of the major pillars of cancer treatment.
Cell-based immunotherapies, which utilize patient's own immune cells to eliminate cancer …

Generation of organoids from urinary tract tumor samples was pioneered a few years ago.
We generated organoids from two upper tract urothelial carcinomas and from one bladder …

Purpose: To investigate the antitumor activity of a mitochondrial-localized HSP90 inhibitor,
Gamitrinib, in multiple glioma models, and to elucidate the antitumor mechanisms of …

Scope Epidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is
correlated with high consumption of fruits and vegetables, which are major sources of fiber …

Synthetic 3D multicellular systems derived from patient tumors, or tumoroids, have been
developed to complete the cancer research arsenal and overcome the limits of current …

Diabetes mellitus is associated with defects in islet β-cell functioning and consequent
hyperglycemia resulting in multi-organ damage. Physiologically relevant models that mimic …

Cancer cells do not exist in isolation; their dynamic interaction with other cells and non-cell
components in the tumor microenvironment (TME) allows them to divide and evolve. Recent …

Highlights•Organoid cultures can be used to overcome limitations observed in 2D
cultures.•Mutagenesis of organoids allows the recapitulation of diseases.•Patient-derived …

Metastasis is the cause of most triple-negative breast cancer deaths, yet anti-metastatic
therapeutics remain limited. To develop new therapeutics to prevent metastasis …

Simple Summary Genome-wide DNA methylation is a regulatory mechanism that is
frequently altered in human cancers. Remarkably, these epigenetic marks on DNA are …