Nanomaterials have gained increasing attention in biomedical research due to their
exclusive physical, chemical and biological properties. Due to their size, which matches the …

Precision medicine has the potential to revolutionize cancer care by identifying promising
treatment strategies specific to each patient's disease. While advances in genome …

BACKGROUND Embryonic stem cells (ESCs) serve as a crucial ex vivo model, representing
epiblast cells derived from the inner cell mass of blastocyst-stage embryos. ESCs exhibit a …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human neoplasms which
remains poorly understood. There is a pressing need to develop a research platform that …

Early detection and predicting treatment response in colorectal cancer (CRC) are two key
strategies to improve CRC survival. Our increasing understanding of the underlying …

Since conventional human cardiac two-dimensional (2D) cell culture and multilayered three-
dimensional (3D) models fail in recapitulating cellular complexity and possess inferior …

Hepatic, biliary and pancreatic (HBP) organoids have proven to be powerful tools in the
study of development, disease and regeneration, with applications ranging from basic …

Cancer treatment development is a complex process, with tumor heterogeneity and inter-
patient variations limiting the success of therapeutic intervention. Traditional two …

Cancer mortality is the second leading cause of death in the United States. It is estimated
that 90% of these are attributed to stage IV metastatic disease, in which tumor cells have …

Evaluating anticancer therapies necessitates a comprehensive understanding of their
efficacy and safety profiles before clinical translation. Models are pivotal in bridging the gap …