Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer

M Rigon, L Mutti, M Campanella - Molecular Oncology, 2024 - Wiley Online Library
Mesothelioma is a type of late‐onset cancer that develops in cells covering the outer surface
of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining …

Immune checkpoint inhibitors as first line in advanced melanoma: Evaluating progression‐free survival based on reconstructed individual patient data

A Ossato, V Damuzzo, P Baldo, D Mengato… - Cancer …, 2023 - Wiley Online Library
Background In patients with advanced melanoma, immune‐checkpoint inhibitors (ICIs)
represent the mainstay for first line treatment. Recently, relatlimab+ nivolumab was …

The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model

PT Graham, AK Nowak, SMJ Cornwall, I Larma… - Frontiers in …, 2022 - frontiersin.org
We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-
mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a …

ATG5 as biomarker for early detection of malignant mesothelioma

M Tomasetti, F Monaco, O Strogovets, L Volpini… - BMC Research …, 2023 - Springer
Objectives Malignant pleural mesothelioma (MPM) is an aggressive disease with grim
prognosis due to lack of effective treatment options. Disease prediction in association with …

Immune checkpoint inhibitors in malignant pleural mesothelioma: a systematic review and meta-analysis

M Gemelli, DL Cortinovis, A Baggi, P di Mauro, S Calza… - Cancers, 2022 - mdpi.com
Simple Summary Many clinical trials have investigated the role of Immune Checkpoint
Inhibitors (ICIs) in pleural mesothelioma (PM), with contrasting results. We performed a …

Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology

T Meirson, V Nardone, F Pentimalli, G Markel… - Journal of Translational …, 2022 - Springer
In this commentary, using existing clinical trial data and FDA approvals we propose that
there is currently a critical need for an appropriate balancing between the financial impact of …

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

F Pentimalli, M Krstic-Demonacos, C Costa… - Frontiers in …, 2023 - frontiersin.org
Introduction Despite increased attention on immunotherapy, primarily immune checkpoint
blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability …

Define the two molecular subtypes of epithelioid malignant pleural mesothelioma

UAK Saddozai, F Wang, S Khattak, MU Akbar, M Badar… - Cells, 2022 - mdpi.com
Malignant pleural mesothelioma (MPM) is a fatal disease of respiratory system. Despite the
availability of invasive biomarkers with promising results, there are still significant diagnostic …

Mesothelioma mouse models with mixed genomic states of chromosome and microsatellite instability

Y Song, SS Baxter, L Dai, C Sanders, S Burkett… - Cancers, 2022 - mdpi.com
Simple Summary Only a limited number of murine mesothelioma cell lines have been
developed to date. We sought to expand this number and to characterize the models in …

[HTML][HTML] The “One-to-Many” Survival Analysis to Evaluate a New Treatment in Comparison With Therapeutic Alternatives Based on Reconstructed Patient Data …

A Messori, M Rivano, L Cancanelli, V Damuzzo… - Cureus, 2022 - ncbi.nlm.nih.gov
Objective This paper presents a preliminary experience based on the" one-to-many"
approach of the Shiny method. Numerous (or" many") treatments for advanced or metastatic …