Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

HY Hwang, JS Shim, D Kim, HJ Kwon - autophagy, 2021 - Taylor & Francis
ABSTRACT Macroautophagy/autophagy (hereafter autophagy), the process of mass
degradation of unnecessary elements within the cell, is often dysregulated in many diseases …

[HTML][HTML] Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

A Upadhyay - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Cells have different sets of molecules for performing an array of physiological functions.
Nucleic acids have stored and carried the information throughout evolution, whereas …

Bioinformatics study of sea cucumber peptides as antibreast cancer through inhibiting the activity of overexpressed protein (EGFR, PI3K, AKT1, and CDK4)

TL Wargasetia, H Ratnawati, N Widodo… - Cancer …, 2021 - journals.sagepub.com
Breast cancer is the most common type of cancer in women globally. The overexpressed
proteins, including EGFR, PI3K, AKT1, and CDK4, have a role in the growth of breast cancer …

Targeting autophagy in disease: recent advances in drug discovery

D Kim, HY Hwang, HJ Kwon - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction Small molecules targeting autophagy have been highly implicated as new
therapeutic agents to treat diseases of interest. With the increasing demand for autophagy …

Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via …

X Yang, L Yao, M Yuan, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide
and worse clinical outcomes compared to AP of other etiologies. Chaiqin chengqi decoction …

[HTML][HTML] Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches

G Selvaraj, S Kaliamurthi, GH Peslherbe… - F1000Research, 2021 - ncbi.nlm.nih.gov
Background: Coronavirus (CoV) is an emerging human pathogen causing severe acute
respiratory syndrome (SARS) around the world. Earlier identification of biomarkers for SARS …

Molecular mechanism analysis of m6A modification-related lncRNA-miRNA-mRNA network in regulating autophagy in acute pancreatitis

X Li, H Qin, A Anwar, X Zhang, F Yu, Z Tan, Z Tang - Islets, 2022 - Taylor & Francis
This study aims to explore the molecular mechanism of N6-methyladenosine (m6A)
modification-related long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger RNA …

Alpha-enolase protects hepatocyte against heat stress through focal adhesion kinase-mediated phosphatidylinositol 3-kinase/akt pathway

T Zeng, Y Cao, T Gu, L Chen, Y Tian, G Li… - Frontiers in …, 2021 - frontiersin.org
Accumulating pieces of evidence showed that α-enolase (ENO1) is a multifunctional protein
that plays a crucial role in a variety of pathophysiological processes. In our previous study …

Nesfatin‐1 inhibits myocardial ischaemia/reperfusion injury through activating Akt/ERK pathway‐dependent attenuation of endoplasmic reticulum stress

RY Su, XY Geng, Y Yang, HS Yin - Journal of cellular and …, 2021 - Wiley Online Library
Abstract Nesfatin‐1 (encoded by NUCB2) is a cardiac peptide possessing protective
activities against myocardial ischaemia/reperfusion (MI/R) injury. However, the regulation of …

LAMA5‐inspired adhesive dodecapeptide facilitates efficient dentine regeneration: An in vitro and in vivo study

J Tang, H Wang, D Wu, Z Wang - International Endodontic …, 2023 - Wiley Online Library
Aim The primary goal of this study was to investigate the potential effects of A5G81 in
inducing reparative dentine (RD) formation both in vitro and in vivo. Methodology Cell …