Role of sulphur-heterocycles in medicinal chemistry: An update
From many decades, S-heterocycles have maintained their status as an important part and
core of FDA approved drugs and medicinally active compounds. With exhaustive exploration …
core of FDA approved drugs and medicinally active compounds. With exhaustive exploration …
In silico prediction of steroids and triterpenoids as potential regulators of lipid metabolism
VM Dembitsky - Marine Drugs, 2021 - mdpi.com
This review focuses on a rare group of steroids and triterpenoids that share common
properties as regulators of lipid metabolism. This group of compounds is divided by the type …
properties as regulators of lipid metabolism. This group of compounds is divided by the type …
Biocatalytic thionation of epoxides for enantioselective synthesis of thiiranes
R Ma, X Hua, CL He, HH Wang, ZX Wang… - Angewandte …, 2022 - Wiley Online Library
Expanding the enzymatic toolbox for the green synthesis of valuable molecules is still of
high interest in synthetic chemistry and the pharmaceutical industry. Chiral thiiranes are …
high interest in synthetic chemistry and the pharmaceutical industry. Chiral thiiranes are …
Asymmetric catalytic (2+ 1) cycloaddition of thioketones to synthesize tetrasubstituted thiiranes
X Lin, M Pu, X Sang, S Li, X Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we report the first example of enantioselective (2+ 1) cycloaddition of thioketones
with α‐diazo pyrazoleamides for the direct synthesis of tetrasubstituted thiiranes. In the …
with α‐diazo pyrazoleamides for the direct synthesis of tetrasubstituted thiiranes. In the …
Sulfated and sulfur-containing steroids and their pharmacological profile
TA Pounina, TA Gloriozova, N Savidov, VM Dembitsky - Marine Drugs, 2021 - mdpi.com
The review focuses on sulfated steroids that have been isolated from seaweeds, marine
sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing …
sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing …
Steroids bearing heteroatom as potential drugs for medicine
VM Dembitsky - Biomedicines, 2023 - mdpi.com
Heteroatom steroids, a diverse class of organic compounds, have attracted significant
attention in the field of medicinal chemistry and drug discovery. The biological profiles of …
attention in the field of medicinal chemistry and drug discovery. The biological profiles of …
Naturally occurring aromatic steroids and their biological activities
VM Dembitsky, N Savidov, VV Poroikov… - Applied microbiology …, 2018 - Springer
The present review describes the distribution and biological activities of natural mono-, di-,
and triaromatic steroids. It is shown that the producers of aromatic steroids are …
and triaromatic steroids. It is shown that the producers of aromatic steroids are …
Antiprotozoal and antitumor activity of natural polycyclic endoperoxides: Origin, structures and biological activity
VM Dembitsky, E Ermolenko, N Savidov, TA Gloriozova… - Molecules, 2021 - mdpi.com
Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi,
and marine invertebrates. The purpose of this review is a comparative analysis of the …
and marine invertebrates. The purpose of this review is a comparative analysis of the …
Hydroperoxy steroids and triterpenoids derived from plant and fungi: Origin, structures and biological activities
VA Vil, AO Terent'ev, N Savidov, TA Gloriozova… - The Journal of Steroid …, 2019 - Elsevier
Hydroperoxides (R-OOH) represent a small family of natural metabolites that have been
isolated from higher plants, fungi, and marine organisms. This paper is devoted to the …
isolated from higher plants, fungi, and marine organisms. This paper is devoted to the …
General Enantioselective and Stereochemically Divergent Four-Stage Approach to Fused Tetracyclic Terpenoid Systems
JM Nicholson, AB Millham, AR Bucknam… - The Journal of …, 2022 - ACS Publications
Tetracyclic terpenoid-derived natural products are a broad class of medically relevant
agents that include well-known steroid hormones and related structures, as well as more …
agents that include well-known steroid hormones and related structures, as well as more …