In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Highly sophisticated and synchronized interactions of various cells and hormonal signals
are required to make organisms competent for reproduction. GnRH neurons act as a …

We evaluated whether the administration of kisspeptin-10 (Kp10) is capable of restoring
gonadal function in hypothyroid male rats. Hypothyroidism was induced with 6-propyl-2 …

Uncovering the central mechanism underlying mammalian reproduction is warranted to
develop new therapeutic approaches for reproductive disorders in humans and domestic …

The obligatory role of kisspeptin (KISS1) and its receptor (KISS1R) in regulating the
hypothalamic-pituitary–gonadal axis, puberty and fertility was uncovered in 2003. In the few …

The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic
neurons in the brain, among which hypothalamic KNDy neurons represent an indispensable …

There is considerable evidence that synchronized activity within a reciprocally connected
population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B …

Background Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the
control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co …

Allostasis provides a supporting role to the homeostatic control of biological variables in
mammalian species. While the concept of homeostasis is related to the control of variables …

The hypothalamus is part of the diencephalon and has several nuclei, one of which is the
arcuate nucleus. The arcuate nucleus of hypothalamus (ARH) consists of neuroendocrine …