Neurodegeneration and demyelination in multiple sclerosis
Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
Parthanatos: Mechanisms, Modulation, and therapeutic prospects in neurodegenerative disease and stroke
Parthanatos is a cell death signaling pathway that has emerged as a compelling target for
pharmaceutical intervention. It plays a pivotal role in the neuron loss and neuroinflammation …
pharmaceutical intervention. It plays a pivotal role in the neuron loss and neuroinflammation …
Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs
R Kumar, P Sood, RK Nirala, A Christian… - Journal for Research in …, 2023 - jrasb.com
Thirty percent of all deaths that occur each year can be attributed to heart disease, stroke,
and other forms of cardiovascular disease. The World Health Organisation (WHO) predicts …
and other forms of cardiovascular disease. The World Health Organisation (WHO) predicts …
PARP1 inhibition prevents oxidative stress in age-related hearing loss via PAR-Ca2+-AIF axis in cochlear strial marginal cells
H Wan, H Chen, J Liu, B Yang, Y Zhang, Y Bai… - Free Radical Biology …, 2024 - Elsevier
Studies have highlighted oxidative damage in the inner ear as a critical pathological basis
for sensorineural hearing loss, especially the presbycusis. Poly (ADP-ribose) polymerase-1 …
for sensorineural hearing loss, especially the presbycusis. Poly (ADP-ribose) polymerase-1 …
Veliparib exerts protective effects in intracerebral hemorrhage mice by inhibiting the inflammatory response and accelerating hematoma resolution
Y Fu, R Liu, Y Zhao, Y Xie, H Ren, Y Wu, B Zhang… - Brain Research, 2024 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have potent anti-inflammatory
effects, including the suppression of brain microglial activation. Veliparib, a well-known …
effects, including the suppression of brain microglial activation. Veliparib, a well-known …
Network pharmacology combined with experimental validation to investigate the effect of Rongjin Niantong Fang on chondrocyte apoptosis in knee osteoarthritis
J Chen, T Zhang, Q Luo, R Wang… - Molecular …, 2024 - spandidos-publications.com
Knee osteoarthritis (KOA) is a chronic degenerative disease that affects the quality of life of
middle‑aged and elderly individuals, and is one of the major factors leading to disability …
middle‑aged and elderly individuals, and is one of the major factors leading to disability …
Synaptic vesicle protein 2 A mitigates parthanatos via apoptosis‐inducing factor in a rat model of pharmacoresistant epilepsy
C Li, Z Wang, M Ren, S Ren, G Wu… - CNS Neuroscience & …, 2024 - Wiley Online Library
Aims Synaptic vesicle protein 2A (SV2A) is a unique therapeutic target for
pharmacoresistant epilepsy (PRE). As seizure‐induced neuronal programmed death …
pharmacoresistant epilepsy (PRE). As seizure‐induced neuronal programmed death …
Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis
F Fan, C Yang, E Piao, J Shi, J Zhang - Biochemical and Biophysical …, 2024 - Elsevier
Osteoarthritis (OA) is a common chronic inflammatory degenerative disease. Since
chondrocytes are the only type of cells in cartilage, their survival is critical for maintaining …
chondrocytes are the only type of cells in cartilage, their survival is critical for maintaining …
Elucidating the impact of parthanatos-related microRNAs on the tumoral immune microenvironment and clinical outcome in low-grade gliomas
P Zhu, H Wu, B Zheng, H Wang, Y Zou - Discover Oncology, 2024 - Springer
Parthanatos, a cell death mechanism triggered by PARP-1 activation, is implicated in
oncogenic processes, yet their role in low-grade gliomas (LGG) remains poorly understood …
oncogenic processes, yet their role in low-grade gliomas (LGG) remains poorly understood …