The CNS is an immune-privileged environment, yet the local control of multiple pathogens is
dependent on the ability of immune cells to access and operate within this site. However …

At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were
reported, and in the following year, SARS resulted in considerable mortality and morbidity …

The chemokine system coordinates leukocyte migration in immunity and inflammation and is
implicated in the pathogenesis of many human diseases. Although several successful …

Several viruses infect the mammalian central nervous system (CNS), some with devastating
consequences, others resulting in chronic or persistent infections associated with little or no …

Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte
infiltration and subsequent axonal damage, demyelinating inflammation, and formation of …

Pro-inflammatory CD4+ T helper (Th) cells drive the pathogenesis of many autoimmune
conditions. Recent advances have modified views of the phenotype of pro-inflammatory Th …

Chemokine receptors have been implicated in a wide range of CNS inflammatory diseases
and have important roles in the recruitment and positioning of immune cells within tissues …

In the first two decades of the 21st century, there have been three outbreaks of severe
respiratory infections caused by highly pathogenic coronaviruses (CoVs) around the world …

In most regions of the central nervous system (CNS), the composition of the neuronal
microenvironment is maintained by virtue of particular blood–brain-barrier (BBB) …

Infection and systemic inflammation are risk factors for cerebrovascular diseases and
poststroke infections impair outcome in stroke patients, although the mechanisms of their …