As the prototype of a family of transcription factors, Sp1 has been extensively studied and
widely reported for its role in gene regulation. The first evidence of Sp1 phosphorylation was …

Neonatal lung diseases may have a genetic background. The available studies mainly
concentrate on surfactant proteins (SP-A, SP-B) and respiratory distress syndrome. Specific …

Objectives Transient tachypnea of the neonate (TTN) is the commonest neonatal respiratory
disorder. Given TTN physiopathology, continuous positive airway pressure (CPAP) could be …

Electrolyte transport across the adult alveolar epithelium plays an important role in
maintaining a thin fluid layer along the apical surface of the alveolus that facilitates gas …

The rise in alveolar oxygen tension (PO2) that occurs as the newborn infant takes its first
breaths induces removal of liquid from the lung lumen due to ion transport across the …

Although genetic factors are assumed to have a role in the etiology of respiratory distress
syndrome (RDS), specific genes underlying this susceptibility are incompletely known. The …

Air pollution continues to be a major public health concern affecting 9 out of 10 individuals
living in urban areas worldwide. Respiratory tract is the organ most exposed to gas pollution …

Background: Transient tachypnea of the newborn (TTN) is usually a benign self-limiting
respiratory disorder in the immediate neonatal period. The lipophilic surfactant-associated …

Exposure of human lung epithelial cells (A549 cell line) to the oxidant pollutant ozone (O 3)
alters cell membrane currents inducing its decrease, when the cell undergoes to a voltage …

Aim: We hypothesized that polymorphisms in the region encoding for the second
transmembrane spanning domain of the epithelial sodium channel may be one factor in the …