Epithelial-to-mesenchymal transition (EMT) is a cellular program which leads to cells losing
epithelial features, including cell polarity, cell–cell adhesion and attachment to the basement …

Hepatocellular carcinoma (HCC) most often develops in patients with underlying liver
disease characterized by chronic nonresolving inflammation. Tumor‐associated …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population
characterized by protumoral functions in the tumor immune network. An increasing number …

Background Polarized macrophages induce fibrosis through multiple mechanisms, including
a process termed epithelial-to-mesenchymal transition (EMT). Mesenchymal cells contribute …

Sorafenib (SOR) resistance remains a major obstacle in the effective treatment of
hepatocellular carcinoma (HCC). A number of long noncoding RNAs (lncRNAs) are …

Purpose Tumor-associated macrophages (TAMs) deserve more focus because of its
clinicopathologic and prognostic roles in solid tumors. However, the prognostic value of …

Background Tumor-associated macrophages (TAMs) are the major immune cells in tumor
microenvironment. The prognostic significance of TAMs has been confirmed in various …

Hepatocellular carcinoma (HCC) is associated with a highly heterogeneous immune
environment that produces an immune response to various locoregional treatments (LRTs) …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death
worldwide. HCC typically develops on a background of chronic inflammation and fibrosis …

Myelofibrosis (MF) is subtype of myeloproliferative neoplasm (MPN) characterized by a
relatively poor prognosis in patients. Understanding the factors that drive MF pathogenesis …