[HTML][HTML] Implementation and implications for polygenic risk scores in healthcare
JL Slunecka, MD van der Zee, JJ Beck, BN Johnson… - Human genomics, 2021 - Springer
Increasing amounts of genetic data have led to the development of polygenic risk scores
(PRSs) for a variety of diseases. These scores, built from the summary statistics of genome …
(PRSs) for a variety of diseases. These scores, built from the summary statistics of genome …
African-American prostate cancer disparities
Abstract Purpose of Review The purpose of this review is to examine prostate cancer racial
disparities specific to the African-American population. Recent Findings African-American …
disparities specific to the African-American population. Recent Findings African-American …
[HTML][HTML] Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study …
Background Prostate cancer is highly heritable, with> 250 common variants associated in
genome-wide association studies. It commonly presents with non-specific lower urinary tract …
genome-wide association studies. It commonly presents with non-specific lower urinary tract …
[PDF][PDF] Genetic factors associated with prostate cancer conversion from active surveillance to treatment
Y Jiang, TJ Meyers, AA Emeka, LF Cooley… - Human Genetics and …, 2022 - cell.com
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active
surveillance (AS) as their initial management strategy. While this may reduce the side effects …
surveillance (AS) as their initial management strategy. While this may reduce the side effects …
Validation of a prostate cancer polygenic risk score
Background Genome‐wide association studies have identified over 100 single‐nucleotide
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …
polymorphisms (SNPs) associated with prostate cancer (PrCa), and polygenic risk scores …
Inherited kidney cancer syndromes
MW Ball, BM Shuch - Current Opinion in Urology, 2019 - journals.lww.com
Inherited kidney cancer syndromes : Current Opinion in Urology Inherited kidney cancer
syndromes : Current Opinion in Urology Log in or Register Subscribe to journalSubscribe Get …
syndromes : Current Opinion in Urology Log in or Register Subscribe to journalSubscribe Get …
Associations between polygenic risk for tobacco and alcohol use and liability to tobacco and alcohol use, and psychiatric disorders in an independent sample of …
Background Substance use, substance use disorders (SUDs), and psychiatric disorders
commonly co-occur. Genetic risk common to these complex traits is an important …
commonly co-occur. Genetic risk common to these complex traits is an important …
Polygenic risk scores in prostate cancer risk assessment and screening
L Byrne, AE Toland - Urologic Clinics, 2021 - urologic.theclinics.com
Prostate cancer (PCa) is the most common cancer among men with a lifetime risk of 12%
and median age of diagnosis of 66. 1 In 2020, 191,930 new cases are expected to be …
and median age of diagnosis of 66. 1 In 2020, 191,930 new cases are expected to be …
Association between polygenic risk for tobacco or alcohol consumption and liability to licit and illicit substance use in young Australian adults
Background Co-morbid substance use is very common. Despite a historical focus using
genetic epidemiology to investigate comorbid substance use and misuse, few studies have …
genetic epidemiology to investigate comorbid substance use and misuse, few studies have …
[HTML][HTML] Association between TMPRSS2: ERG fusion gene and the prostate cancer: systematic review and meta-analysis
HA García-Perdomo, MJ Chaves… - … European Journal of …, 2018 - ncbi.nlm.nih.gov
Results We found 241 records with the search strategies. After duplicates were removed, 18
studies were included in qualitative analysis and 15 studies in meta-analysis. All included …
studies were included in qualitative analysis and 15 studies in meta-analysis. All included …