Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …

A universal characteristic of eukaryotic transcription is that the promoter recruits RNA
polymerase II (RNAPII) to produce both precursor mRNAs (pre-mRNAs) and short unstable …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

Initially discovered by genetic screens in budding yeast, SPT5 and its partner SPT4 form a
stable complex known as DSIF in metazoa, which plays pleiotropic roles in multiple steps of …

Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …

Abstract RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …

Abstract Histone variant H2A. Z is found at promoters and regulates transcription. The ATP-
dependent chromatin remodeler SRCAP complex (SRCAP-C) promotes the replacement of …

Abstract RNA polymerase II (RNAPII) is an essential machinery for catalyzing mRNA
synthesis and controlling cell fate in eukaryotes. Although the structure and function of …

Infection with human papillomavirus (HPV) is a major risk factor for head and neck
squamous cell carcinoma (HNSCC). The objective of this study is to investigate the gene …

Das Rauchen ist einer der wichtigsten vermeidbaren Risikofaktoren für Morbidität und
Mortalität weltweit. Der Konsum von Tabak ist dabei mit einer Vielzahl unterschiedlicher …