A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …

Since the establishment of a canonical animal microRNA biogenesis pathway driven by the
RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that …

Multicellular organisms initiate adaptive responses when oxygen (O 2) availability
decreases, but the underlying mechanism of O 2 sensing remains elusive. We find that …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

RNA interference (RNAi) was first recognized in Caenorhabditis elegans as a biological
response to exogenous double-stranded RNA (dsRNA), which induces sequence-specific …

In antiviral RNA interference (RNAi), the DICER enzyme processes virus-derived double-
stranded RNA (dsRNA) into small interfering RNAs (siRNAs) that guide ARGONAUTE …

Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …

Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species
responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post …

Short interfering RNAs can be used to silence gene expression in a sequence-specific
manner in a process that is known as RNA interference. The application of RNA interference …

In the present study, the relationship between short interfering RNA (siRNA) sequence and
RNA interference (RNAi) effect was extensively analyzed using 62 targets of four exogenous …