Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

OBJECTIVES: This review is focused on the influence of oxygen and derived reactive
species on chondrocytes aging, metabolic function and chondrogenic phenotype …

Osteoarthritis (OA) is a chronic joint disease and its progression and pathogenesis are
highly associated with the significant increase of joint friction and overproduction of reactive …

Despite the severity of osteoarthritis (OA), current medical therapy strategies for OA aim at
symptom control and pain reduction, as there is no ideal drug for effective OA treatment. OA …

Fundamental to rational, safe, and effective treatment for any orthopaedic condition is an
accurate understanding of the etiology of the symptoms. The decades-old paradigm of a …

Aging and inflammation are major contributing factors to the development and progression
of arthritic and musculoskeletal diseases.“Inflammaging” refers to low-grade inflammation …

Hyaluronan is being used increasingly as a component of artificial matrices and in
bioengineering for tissue scaffolding. The length of hyaluronan polymer chains is now …

Several epidemiological and experimental data support the hypothesis that diabetes could
be an independent risk factor for osteoarthritis (OA), at least in some patients, leading to the …

Rheumatoid arthritis (RA) and adult periodontitis share common pathogenetic mechanisms
and immunologic and pathological findings. One oral pathogen strongly implicated in the …

Chondrocytes communicate with each other mainly via diffusible signals rather than direct
cell‐to‐cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is …