OBJECTIVES: Curcumin (diferuloylmethane) is the principal biochemical component of the
spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and …

Background Most in vitro studies of potential osteoarthritis (OA) therapies have used
cartilage monocultures, even though synovium is a key player in mediating joint …

Ayurveda is a Sanskrit word, which means “the scripture for longevity”. It represents an
ancient system of traditional medicine prevalent in India and in several other south Asian …

Abstract cellular level is not completely understood, but both aging and loading-induced
stresses have been shown to undermine cell functions related to the maintenance and …

Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may
favor the development and/or progression of osteoarthritis (OA). Thus far, little is known …

The purpose of this study was to determine serum oxidative/antioxidative status in patients
with knee osteoarthritis and its relation with prolidase activity, which plays an important role …

The extracellular compartments of most biological tissues are significantly less well
protected against oxidative damage than intracellular sites and there is considerable …

Turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have
been widely used as dietary spices and to treat different diseases in Ayurveda/Chinese …

Microcrystals of calcium pyrophosphate dihydrate (CPPD) and monosodium urate (MSU)
deposited in synovium and articular cartilage initiate joint inflammation and cartilage …

Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in cells
as part of normal physiology but more frequently manifested in the pathophysiology of many …