A comprehensive literature review and expert consensus statement on therapeutic drug monitoring of biologics in inflammatory bowel disease

AS Cheifetz, MT Abreu, W Afif, RK Cross… - Official journal of the …, 2021 - journals.lww.com
Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aimed to
provide a consensus statement regarding the clinical utility of TDM for biologics in …

[HTML][HTML] Appropriate therapeutic drug monitoring of biologic agents for patients with inflammatory bowel diseases

K Papamichael, AS Cheifetz, GY Melmed… - Clinical …, 2019 - Elsevier
Background & Aims Therapeutic drug monitoring (TDM) is widely available for biologic
therapies in patients with inflammatory bowel disease (IBD). We reviewed current data and …

ECCO guidelines on therapeutics in ulcerative colitis: medical treatment

T Raine, S Bonovas, J Burisch… - Journal of Crohn's …, 2022 - academic.oup.com
Ulcerative colitis [UC] is a chronic inflammatory bowel disease [IBD] characterised by colonic
inflammation extending to a variable extent from the rectum. Care of the patient with UC …

Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives

K Papamichael, W Afif, D Drobne… - The lancet …, 2022 - thelancet.com
Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimising the use of
biologics, and in particular anti-tumour necrosis factor (anti-TNF) therapy, in inflammatory …

Therapeutic drug monitoring with biologic agents in immune mediated inflammatory diseases

K Papamichael, EH Vogelzang, J Lambert… - Expert review of …, 2019 - Taylor & Francis
Introduction: Biologic therapy has revolutionized the treatment of immune mediated
inflammatory diseases (IMID), such as inflammatory bowel disease (IBD), rheumatoid and …

How, when, and for whom should we perform therapeutic drug monitoring?

S Vermeire, E Dreesen, K Papamichael… - Clinical …, 2020 - Elsevier
The implementation of therapeutic drug monitoring (TDM) in the inflammatory bowel disease
practice has evolved over the years. In the early days, the focus was merely on measuring …

Therapeutic drug monitoring of biologics during induction to prevent primary non-response

MP Sparrow, K Papamichael, MG Ward… - Journal of Crohn's …, 2020 - academic.oup.com
Biologic therapies have revolutionized the management of inflammatory bowel disease
[IBD], but primary and secondary non-responses occur in a significant proportion of patients …

Transitioning from intravenous to subcutaneous vedolizumab in patients with inflammatory bowel disease [TRAVELESS]

E Ventress, D Young, S Rahmany… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Subcutaneous [SC] vedolizumab presents the opportunity for
inflammatory bowel disease [IBD] patients to manage their treatment at home. There are …

Residual homing of α4β7-expressing β1+ PI16+ regulatory T cells with potent suppressive activity correlates with exposure-efficacy of vedolizumab

E Becker, M Dedden, C Gall, M Wiendl, AB Ekici… - Gut, 2022 - gut.bmj.com
Objective The anti-α4β7 integrin antibody vedolizumab is administered at a fixed dose for
the treatment of IBDs. This leads to a wide range of serum concentrations in patients and …

Comparison of short‐and long‐term effectiveness between ustekinumab and vedolizumab in patients with Crohn's disease refractory to anti‐tumour necrosis factor …

L Manlay, G Boschetti, B Pereira… - Alimentary …, 2021 - Wiley Online Library
Background The best option between vedolizumab and ustekinumab after anti‐tumour
necrosis factor (TNF) failure remains unclear in Crohn's disease. Aims To compare the short …