[HTML][HTML] Targeting a Sirt5-positive subpopulation overcomes multidrug resistance in wild-type Kras colorectal carcinomas
ZG Du, XJ Liu, T Chen, WC Gao, ZM Wu, ZQ Hu, D Wei… - Cell reports, 2018 - cell.com
A major obstacle for successful management of patients with colorectal carcinoma (CRC) is
resistance to anti-cancer cytotoxic treatments. Here, we identified a mechanism of multidrug …
resistance to anti-cancer cytotoxic treatments. Here, we identified a mechanism of multidrug …
Epidemiology and molecular-pathologic characteristics of CpG Island methylator phenotype (CIMP) in colorectal cancer
Background CpG island methylator phenotype (CIMP) forms a distinct epigenetic phenotype
in colorectal cancer (CRC). Though associated with distinct clinicopathologic characteristics …
in colorectal cancer (CRC). Though associated with distinct clinicopathologic characteristics …
[HTML][HTML] Prognostic implications of mucinous differentiation in metastatic colorectal carcinoma can be explained by distinct molecular and clinicopathologic …
Background The mucinous histologic subtype accounts for 5% to 20% of colorectal cancer
(CRC) cases but remains poorly characterized. The present study characterized the …
(CRC) cases but remains poorly characterized. The present study characterized the …
[HTML][HTML] A review of the sensitivity of metastatic colorectal cancer patients with deficient mismatch repair to standard-of-care chemotherapy and monoclonal antibodies …
E Wensink, M Bond, E Kucukkose, A May, G Vink… - Cancer Treatment …, 2021 - Elsevier
In 5% of metastatic colorectal cancer (mCRC) patients, tumours display a deficient mismatch
repair (dMMR) system. Immunotherapy is beneficial in dMMR mCRC patients and has …
repair (dMMR) system. Immunotherapy is beneficial in dMMR mCRC patients and has …
Methylation analysis of Gasdermin E shows great promise as a biomarker for colorectal cancer
J Ibrahim, K Op de Beeck, E Fransen, L Croes… - Cancer …, 2019 - Wiley Online Library
In addition to its implication in hereditary hearing loss, the Gasdermin E (GSDME) gene is
also a tumor suppressor involved in cancer progression through programmed cell death …
also a tumor suppressor involved in cancer progression through programmed cell death …
Amphiregulin Expression Is a Predictive Biomarker for EGFR Inhibition in Metastatic Colorectal Cancer: Combined Analysis of Three Randomized Trials
A Stahler, S Stintzing, DP Modest, I Ricard… - Clinical Cancer …, 2020 - AACR
Purpose: Amphiregulin (AREG) and epiregulin (EREG) are ligands of EGFR. Predictive
information for anti-EGFR treatment in metastatic colorectal cancer (mCRC) was observed …
information for anti-EGFR treatment in metastatic colorectal cancer (mCRC) was observed …
CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
HM Vedeld, M Merok, M Jeanmougin… - … journal of cancer, 2017 - Wiley Online Library
The prognostic value of CpG island methylator phenotype (CIMP) in colorectal cancer
remains unsettled. We aimed to assess the prognostic value of this phenotype analyzing a …
remains unsettled. We aimed to assess the prognostic value of this phenotype analyzing a …
Meta‐Analysis of the Prognostic and Predictive Role of the CpG Island Methylator Phenotype in Colorectal Cancer
J Wang, Z Deng, X Lang, J Jiang, K Xie, S Lu… - Disease …, 2022 - Wiley Online Library
Background. Various studies have produced contradictory results on the prognostic role of
the CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients …
the CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients …
The predictive value of primary tumor location in patients with metastatic colorectal cancer: a systematic review
N Boeckx, K Janssens, G Van Camp… - Critical Reviews in …, 2018 - Elsevier
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. It has
been reported that left-and right-sided CRC harbor varying disease characteristics, which …
been reported that left-and right-sided CRC harbor varying disease characteristics, which …
[HTML][HTML] Impact of primary tumor location in patients with RAS wild-type metastatic colon cancer treated with first-line chemotherapy plus anti-EGFR or anti-VEGF …
A Grassadonia, P Di Marino, C Ficorella… - Journal of …, 2019 - ncbi.nlm.nih.gov
Emerging evidence supports a prognostic role of primary tumor location in metastatic colon
cancer (mCC). We conducted a retrospective analysis to evaluate the effect of tumor location …
cancer (mCC). We conducted a retrospective analysis to evaluate the effect of tumor location …