A major obstacle for successful management of patients with colorectal carcinoma (CRC) is
resistance to anti-cancer cytotoxic treatments. Here, we identified a mechanism of multidrug …

Background CpG island methylator phenotype (CIMP) forms a distinct epigenetic phenotype
in colorectal cancer (CRC). Though associated with distinct clinicopathologic characteristics …

Background The mucinous histologic subtype accounts for 5% to 20% of colorectal cancer
(CRC) cases but remains poorly characterized. The present study characterized the …

In 5% of metastatic colorectal cancer (mCRC) patients, tumours display a deficient mismatch
repair (dMMR) system. Immunotherapy is beneficial in dMMR mCRC patients and has …

In addition to its implication in hereditary hearing loss, the Gasdermin E (GSDME) gene is
also a tumor suppressor involved in cancer progression through programmed cell death …

Purpose: Amphiregulin (AREG) and epiregulin (EREG) are ligands of EGFR. Predictive
information for anti-EGFR treatment in metastatic colorectal cancer (mCRC) was observed …

The prognostic value of CpG island methylator phenotype (CIMP) in colorectal cancer
remains unsettled. We aimed to assess the prognostic value of this phenotype analyzing a …

Background. Various studies have produced contradictory results on the prognostic role of
the CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients …

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. It has
been reported that left-and right-sided CRC harbor varying disease characteristics, which …

Emerging evidence supports a prognostic role of primary tumor location in metastatic colon
cancer (mCC). We conducted a retrospective analysis to evaluate the effect of tumor location …