[HTML][HTML] Right-vs. left-sided metastatic colorectal cancer: differences in tumor biology and bevacizumab efficacy
P Ulivi, E Scarpi, E Chiadini, G Marisi… - International journal of …, 2017 - mdpi.com
There is evidence of a different response to treatment with regard to the primary tumor
localization (right-sided or left-sided) in patients with metastatic colorectal cancer (mCRC) …
localization (right-sided or left-sided) in patients with metastatic colorectal cancer (mCRC) …
[HTML][HTML] Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs
Background Biomarker discovery in colorectal cancer has mostly focused on methylation
patterns in normal and colorectal tumor tissue, but adenomas remain understudied …
patterns in normal and colorectal tumor tissue, but adenomas remain understudied …
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics
IA Voutsadakis - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
Background Colorectal cancer is one of the most prevalent malignancies and its molecular
pathogenesis has been intensely investigated for several decades. As a result, great …
pathogenesis has been intensely investigated for several decades. As a result, great …
[PDF][PDF] Differences in clinical features and oncologic outcomes between metastatic right and left colon cancer
K Kim, YW Kim, H Shim, BR Kim, HY Kwon - J buon, 2018 - researchgate.net
Summary Approximately 20% to 25% of patients with colorectal cancer (CRC) have distant
organ metastasis at the time of initial diagnosis. The primary tumor location has been …
organ metastasis at the time of initial diagnosis. The primary tumor location has been …
[HTML][HTML] Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer
Y Shimada, H Kameyama, M Nagahashi, H Ichikawa… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Objectives Anti-epidermal growth factor receptor (EGFR) therapy has been found to be more
effective against left-sided colorectal cancer (LCRC) than right-sided colorectal cancer …
effective against left-sided colorectal cancer (LCRC) than right-sided colorectal cancer …
Prognostic value of methylator phenotype in stage III colon cancer treated with oxaliplatin-based adjuvant chemotherapy
Purpose: There are conflicting results concerning the prognostic value of the CpG island
methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this …
methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this …
[HTML][HTML] Wingless/It/β-catenin signaling in liver metastasis from colorectal cancer: A focus on biological mechanisms and therapeutic opportunities
F Selvaggi, T Catalano, R Lattanzio… - World Journal of …, 2023 - ncbi.nlm.nih.gov
The liver is the most common site of metastases in patients with colorectal cancer. Colorectal
liver metastases (CRLMs) are the result of molecular mechanisms that involve different cells …
liver metastases (CRLMs) are the result of molecular mechanisms that involve different cells …
[HTML][HTML] Impact of primary tumour location and RAS/BRAF mutational status in metastatic colorectal cancer treated with first-line regimens containing oxaliplatin and …
S Hegewisch-Becker, S Nöpel-Dünnebacke… - European Journal of …, 2018 - Elsevier
Background The major prognostic relevance of primary tumour location (LPT) in advanced
colorectal cancer was shown in large retrospective studies, but quantitative estimates are …
colorectal cancer was shown in large retrospective studies, but quantitative estimates are …
Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer
F Bormann, S Stinzing, S Tierling… - … Journal of Cancer, 2019 - Wiley Online Library
Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin
(EREG) is positively correlated with a response to EGFR‐targeted therapies in colorectal …
(EREG) is positively correlated with a response to EGFR‐targeted therapies in colorectal …
[HTML][HTML] Significance of amphiregulin (AREG) for the outcome of low and high grade astrocytoma patients
Background: Amphiregulin (AREG) is one of the ligands of the epidermal growth factor
receptor which levels was shown to have a tight coherence with various types of cancer …
receptor which levels was shown to have a tight coherence with various types of cancer …