Background Broad copy number aberrations (BCNAs) represent a common form of genome
instability in colorectal cancer (CRC). CRCs show large variations in their level of …

Sarcoma cancers are uncommon malignant tumors, and there are many subgroups,
including fibrosarcoma (FS), which mainly affects middle-aged and older adults in deep soft …

Methods: The systematic review and meta-analysis was designed, undertaken and reported
using items from the PRISMA statement. Relevant articles were identified through PubMed …

Motivation DNA methylation is a key epigenetic factor regulating gene expression. While
promoter methylation has been well studied, recent publications have revealed that …

Purpose The genome-wide DNA methylation status (GWMS) predicts of therapeutic
response to anti-epidermal growth factor receptor (EGFR) antibodies in treating metastatic …

Abstract Purpose The CpG island methylator phenotype (CIMP), important for
carcinogenesis, is a predictor of prognosis and chemotherapy sensitivity in colorectal cancer …

Background Varieties of systemic treatments in second-line treatment for metastatic
colorectal cancer (mCRC) patients have showed an improvement on survival. In this study …

The cetuximab gene expression signature and DNA methylation status of colorectal cancer
(CRC) are predictive of the therapeutic effects of anti‐epidermal growth factor receptor …

Background/Aim: Amphiregulin (AREG) and epiregulin (EREG) mRNA expression levels are
predictors of response to anti-EGFR antibody therapy. Left-sided colon cancer is more …

Aim: This meta-analysis aimed to document the impact of primary tumor site on anti-EGFR
monoclonal antibody (mAb) benefit in metastatic colorectal cancer. Materials & methods …