Aim: This meta-analysis aimed to document the impact of primary tumor site on anti-EGFR
monoclonal antibody (mAb) benefit in metastatic colorectal cancer. Materials & methods …

p130 Crk-associated substrate (p130Cas) is associated with poor prognosis and treatment
resistance in breast and lung cancers. To elucidate p130Cas functional and clinical role in …

The discovery of epidermal growth factor (EGF) and its receptor (EGFR) revealed the
connection between EGF-like ligands, signaling from the EGFR family members and cancer …

Amphiregulin is a member of the EGFR family, which is involved in many physiological and
pathological processes through its binding with EGFR. Studies have found that amphiregulin …

Background Little is known about the biweekly combined use of cetuximab and
chemotherapy as second-line treatment of metastatic colorectal cancer (mCRC). Recently …

The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with
the introduction of novel targeted agents and new therapeutic strategies for the metastatic …

Abstract Purpose of Review During the past few years, several important clinical and
molecular differences have been observed simply based on anatomic tumor location of …

Purpose Outcomes for patients with metastatic colorectal cancer (mCRC) have been
improved by the identification of biomarkers predictive and prognostic of clinical outcome …

Infection with the human papillomaviruses (HPV) often involves the epigenetic modification
of the host genome. Despite its prevalence among the population, host genome methylation …

Objective As a unique histological subtype of colorectal cancer (CRC), mucinous
adenocarcinoma (MC) has a poor prognosis and responds poorly to treatment. Genes and …