For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

The lysosomal aspartic protease cathepsin D (cath-D) is over-expressed and hyper-secreted
by epithelial breast cancer cells. This protease is an independent marker of poor prognosis …

Background Elevated SNCA gene expression and intracellular accumulation of the encoded
α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD) …

Carcinoma cells initiate the metastatic cascade by inserting invasive pseudopodia through
breaches in the basement membrane (BM), a specialized barrier of cross-linked …

Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from
Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with …

Abstract Cathepsin D (Cat D) is well known for its roles in metastasis, angiogenesis,
proliferation, and carcinogenesis in cancer. Despite Cat D being a promising target in …

Neuronal ceroid lipofuscinoses (NCL) comprise a group of inherited lysosomal disorders
with variable age of onset, characterized by lysosomal accumulation of autofluorescent …

The current mechanism proposed for the processing and activation of the 52 kDa lysosomal
aspartic protease cathepsin D (cath-D) is a combination of partial auto-activation generating …

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic
malignancies and has a poor prognosis due to relatively unspecific early symptoms, and …

Background Triple-negative breast cancer (TNBC) treatment is currently restricted to
chemotherapy. Hence, tumor-specific molecular targets and/or alternative therapeutic …