Alzheimer's disease (AD) is a progressive neurogenerative disorder manifested by gradual
memory loss and cognitive decline due to profound damage of cholinergic neurons. The …

Infectious and many non-infectious diseases share common molecular mechanisms. Among
them, oxidative stress and the subsequent inflammatory reaction are of particular note …

Background Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated
with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit …

Presently, there is a lack of effective disease-modifying drugs for the treatment of Alzheimer's
disease (AD). Uncaria rhynchophylla (UR) and its predominant active phytochemicals …

Abstract C–C chemokine receptor 5 (CCR5) is a chemokine receptor involved in immune
responses and a co-receptor for HIV infection. Recently, CCR5 has also been reported to …

Accumulating evidence highlights chemokines as key mediators of the bidirectional
crosstalk between neurons and glial cells aimed at preserving brain functioning. The …

Vascular dementia (VaD) is considered to be the second most common form of dementia
after Alzheimer's disease, and no specific drugs have been approved for VaD treatment. We …

CCR5 plays a central role in infectious disease, host defense, and cancer progression,
thereby making it an ideal target for therapeutic development. Notably, CCR5 is the major …

The dried and ripe fruits of Alpinia oxyphylla and ripe fruits of Alpinia oxyphylla Miquel (AO)
have the effects of tonifying kidney-essence and nourishing intelligence and thus have been …

Introduction Excessive immune activation induces tissue damage during infection.
Compared to external strategies to reconstruct immune homeostasis, host balancing ways …