Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely
tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking …

Energy release from cellular storage is mandatory for survival during fasting. This is
achieved through lipolysis and liver gluconeogenesis. We show here that in the mouse, gut …

Endogenous pancreatic β cell regeneration is a potential strategy for β cell expansion or
neogenesis to treat diabetes. Regeneration can occur through stimulation of existing β cell …

In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic
islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell …

Gestational diabetes mellitus (GDM) is defined as the presence of high blood glucose levels
with the onset, or detected for the first time during pregnancy, as a result of increased insulin …

Insulin resistance is a cornerstone of obesity-related complications such as type 2 diabetes,
metabolic syndrome, and nonalcoholic fatty liver disease. A high rate of lipolysis is known to …

Diabetes is a common metabolic complication of pregnancy and affected women fall into two
subgroups: women with pre-existing diabetes and those with gestational diabetes mellitus …

The pancreatic islet secretes the hormones insulin and glucagon to regulate glucose
metabolism. To generate an adequate secretory response, islet endocrine cells must receive …

The homoeostatic regulation of metabolism is highly complex and involves multiple inputs
from both the nervous and endocrine systems. The gut is the largest endocrine organ in our …

This is the third in a series of Perspectives on intracellular signaling pathways coupled to
proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells …