The choroid plexus (ChP) is a highly vascularized tissue found in the brain ventricles, with
an apical epithelial cell layer surrounding fenestrated capillaries. It is responsible for the …

Background And Aims Destroying visceral sensory nerves impacts pancreatic islet function,
glucose metabolism, and diabetes onset, but how islet endocrine cells interact with sensory …

Objective As diabetes develops, marked reductions of insulin secretion are associated with
very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell …

Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the
developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity …

Integrative organ crosstalk regulates key aspects of energy homeostasis, and its
dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the …

It has been suggested that new beta cells can arise from specific populations of adult
pancreatic progenitors or facultative stem cells. However, their existence remains …

Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …

Background A number of case-control studies were conducted to investigate the association
of common type 2 diabetes (T2D) risk gene polymorphisms with gestational diabetes …

In recent years, the incidence rate of diabetes mellitus (DM), including type 1 diabetes
mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) …

The first step in serotonin (5-HT) biosynthesis is catalyzed by tryptophan hydroxylase (TPH).
There are two independent sources of the monoamine that have distinct functions: first, the …