Pathogenesis of allergic diseases and implications for therapeutic interventions
J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?
The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …
therapeutic target in cancer therapy. It has been well established that transcription factor NF …
Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects
HY Estupiñán, A Berglöf, R Zain… - Frontiers in cell and …, 2021 - frontiersin.org
The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …
[HTML][HTML] The amoeboid state as part of the epithelial-to-mesenchymal transition programme
V Graziani, I Rodriguez-Hernandez, O Maiques… - Trends in cell …, 2022 - cell.com
Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …
NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …
Therapeutic targeting of NF-κB in acute lung injury: a double-edged sword
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK) family. TBK1 can be activated by …
Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects
A Dahchour - Pharmacological Research, 2022 - Elsevier
Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …
Role of NF-κB in ageing and age-related diseases: lessons from genetically modified mouse models
VA García-García, JP Alameda, A Page, ML Casanova - Cells, 2021 - mdpi.com
Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and
environmental factors. It is manifested by a decline in the physiological functions of …
environmental factors. It is manifested by a decline in the physiological functions of …
NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
A Oh, M Pardo, A Rodriguez, C Yu, L Nguyen… - Cell Communication and …, 2023 - Springer
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …
mediators of inflammatory signaling. The NF-κB signaling is dysregulated in a significant …