Depression is common in older adults and those with cardiovascular disease. Although
selective serotonin reuptake inhibitors generally have been shown to be safe to treat …

Introduction The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is
among the most prescribed antidepressant drugs worldwide and, according to guidelines, its …

Therapeutic drug monitoring is a tool for optimising the pharmacological treatment of
diseases where the therapeutic effect is difficult to measure or monitor. Therapeutic …

Abstract Background Therapeutic Drug Monitoring (TDM) represents one of the most
promising tools in clinical practice to optimise antidepressant treatment. Nevertheless, little …

The management of pharmacokinetics and pharmacodynamics of drugs constitutes an
approach for personalizing pharmacotherapy. This can be achieved by controlling …

Background Venlafaxine (VEN) and its O-demethylated metabolite, O-desmethylvenlafaxine
(ODV), are commonly prescribed serotonin-norepinephrine reuptake inhibitors, approved for …

Background: The optimal antidepressant dosages remain controversial. This study aimed to
analyze the efficacy of antidepressants and characterize their dose–response relationships …

We studied the role of JNK in the regulation of the metabolism of xenobiotic venlafaxine by
liver cells under in vitro conditions. The inhibitory role of this protein kinase in the …

Background Psychotropic medicine utilisation in older adults continues to be of interest
because of overuse and concerns surrounding its safety and efficacy. Objective This study …

Résumé La venlafaxine est le troisième antidépresseur le plus fréquemment prescrit en
France la dernière décennie, avec environ 400 000 doses journalières. Le suivi …