Daphnetin (DAP), a coumarin derivative extracted from Daphne species, is biologically
active phytochemical with copious bioactivities including anti-inflammatory, anti-oxidant …

Coumarins is a huge family of phenolic compounds containing a common structure of 2H‐1‐
benzopyran‐2‐one. Nowadays, more than 1,300 natural‐based coumarins have been …

Demethylzeylasteral (DEM), a class of terpenoids isolated from natural plants, frequently
exhibits moderate or limited inhibitory effect on tumor growth across multiple cancer types …

Abstract Daphnetin (7, 8-dihydroxy-coumarin, DAPH) is a naturally occurring coumarin
presenting a wide array of biological activities. In the present study, daphnetin and its novel …

To expand the range of daphnetin-based inhibitors/activators used for targeting G protein-
coupled receptors (GPCRs) in disease treatment, twenty-five coumarin derivatives 1–25 …

A library of new coumarin‐1, 2, 3‐triazole hybrids 7a–l were synthesized from 4‐
(diethylamino)‐2‐hydroxybenzaldehyde precursor through a series of reactions including …

Protein tyrosine phosphatase (PTP1B) antagonizes insulin signaling and acts as a potential
therapeutic target for insulin resistance associated with obesity and type II diabetes. In this …

2, 5-Bis-[8-(4, 8-dimethyl-nona-3, 7-dienyl)-5, 7-dihydroxy-8-methyl-3-keto-1, 2, 7, 8-
teraahydro-6 H-pyran [a] isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran …

Aim: A novel series of fused benzochromenes with expected cytotoxicity and HIF-1α
inhibition was identified. Materials & methods: A bioisosterism-aided approach was applied …

Abstract Daphnetin (7, 8-dihydroxycoumarin) and esculin (6, 7-dihydroxycoumarin-β-D-
glucopyranoside) are natural coumarins that have gained increasing research attention over …