[HTML][HTML] Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines

WG Dos Santos - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) continues to challenge most scientists in the
search of an effective way to either prevent infection or to avoid spreading of the disease. As …

Coronavirus genomic nsp14‐ExoN, structure, role, mechanism, and potential application as a drug target

M Tahir - Journal of Medical Virology, 2021 - Wiley Online Library
The recent coronavirus disease 2019 (COVID‐19), causing a global pandemic with
devastating effects on healthcare and social‐economic systems, has no special antiviral …

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

J Gribble, LJ Stevens, ML Agostini… - PLoS …, 2021 - journals.plos.org
Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of
SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal …

A review of pseudorabies virus variants: genomics, vaccination, transmission, and zoonotic potential

Z Bo, X Li - Viruses, 2022 - mdpi.com
Pseudorabies virus (PRV), the causative agent of Aujeszky's disease, has a broad host
range including most mammals and avian species. In 2011, a PRV variant emerged in many …

Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains

J Guo, L Fang, X Ye, J Chen, S Xu… - Transboundary and …, 2019 - Wiley Online Library
Porcine epidemic diarrhea virus (PEDV), which re‐emerged in China in October 2010, has
spread rapidly worldwide. Detailed analyses of the complete genomes of different PEDV …

Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease

P Wang, J Bai, X Liu, M Wang, X Wang, P Jiang - Veterinary research, 2020 - Springer
Porcine epidemic diarrhea virus (PEDV) causes lethal diarrhea in suckling piglets, leading
to severe economic losses worldwide. There is an urgent need to find new therapeutic …

Genetic characterization and phylogenetic analysis of porcine epidemic diarrhea virus in Guangdong, China, between 2018 and 2019

F Wen, J Yang, A Li, Z Gong, L Yang, Q Cheng… - PLoS …, 2021 - journals.plos.org
Porcine epidemic diarrhea virus (PEDV), a leading cause of piglet diarrhea outbreaks,
poses a significant danger to the swine industry. The aim of this study was to investigate the …

Immune evasion mechanisms of porcine epidemic diarrhea virus: A comprehensive review: https://doi. org/10.12982/VIS. 2024.014

FL Orosco - Veterinary Integrative Sciences, 2024 - he02.tci-thaijo.org
Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes
significant economic losses to the swine industry worldwide. Understanding the host …

The reassessed potential of SARS-CoV-2 attenuation for COVID-19 vaccine development—A systematic review

M Goławski, P Lewandowski, I Jabłońska, M Delijewski - Viruses, 2022 - mdpi.com
Live-attenuated SARS-CoV-2 vaccines received relatively little attention during the COVID-
19 pandemic. Despite this, several methods of obtaining attenuated coronaviruses are …

Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

J Gutiérrez-Álvarez, JM Honrubia… - Proceedings of the …, 2021 - National Acad Sciences
Self-amplifying RNA replicons are promising platforms for vaccine generation. Their defects
in one or more essential functions for viral replication, particle assembly, or dissemination …