Neuroendocrine prostate cancer (NEPC) is a multi-resistant variant of prostate cancer (PCa)
that frequently emerges in castration-resistant prostate cancer (CRPC). NEPC is usually …

The long non-coding RNA X-inactive specific transcript (lncRNA XIST) and MUC1 gene are
dysregulated in chronic inflammation and cancer; however, there is no known interaction of …

Long non-coding RNAs (lncRNAs) have emerged as influential contributors to diverse
cellular processes, which regulate gene function and expression via multiple mechanistic …

The construction of reliable preclinical models is crucial for understanding the molecular
mechanisms involved in gastric cancer and for advancing precision medicine. Currently …

BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been
shown to be highly expressed in several cancers and promotes tumor cell migration. This …

Previous evidence has confirmed that branched-chain aminotransferase-1 (BCAT1), a key
enzyme governing branched-chain amino acid (BCAA) metabolism, has a role in cancer …

Cancer stem cells (CSCs) are pivotal in both cancer progression and the acquisition of drug
resistance. MicroRNAs (miRNAs) play a crucial role in modulating CSC properties and are …

Human induced pluripotent stem cells (hiPSCs) hold considerable promise for autologous
cellular therapies, particularly in ocular disease treatment, because of the low numbers of …

This thesis explores the role of intrinsically disordered proteins and regions in the eukaryotic
nucleus, focusing particularly on the pioneer transcription factor Sox2. Sox2 is well known …