Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …

Endothelial barrier function is an essential and tightly regulated process that ensures proper
compartmentalization of the vascular and interstitial space, while allowing for the diffusive …

Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine that also
increases vascular permeability. Nitric oxide (NO) released from endothelial cells, after …

Previous studies have indicated that acute increases in shear stress can stimulate
endothelial nitric oxide synthase (eNOS) activity through increased PI3 kinase/Akt signaling …

In an ovine model of persistent pulmonary hypertension of the newborn (PPHN), endothelin-
1 (ET-1) expression is increased, while endothelial nitric oxide synthase (eNOS) expression …

Neuropeptide modulation of immune cell function is an important mechanism of
neuroimmune intersystem crosstalk. Substance P (SP) is one such key neuropeptide …

Background Previous studies have indicated that protein kinase C (PKC) may enhance
endothelial nitric oxide synthase (eNOS) activation, although the detailed mechanism (s) …

The balance between endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) and
reactive oxygen species (ROS) production determines endothelial-mediated vascular …

ADP responses underlie therapeutic approaches to many cardiovascular diseases, and
ADP receptor antagonists are in widespread clinical use. The role of ADP in platelet biology …

Background: Endothelium and K+ channel functionality in smooth muscle cells (SMCs)
regulates vascular function and is exposed to damage in diabetes. The regulatory enzyme …