A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …

The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …

The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …

The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

The precise mechanism by which oral infection contributes to the pathogenesis of extra-oral
diseases remains unclear. Here, we report that periodontal inflammation exacerbates gut …

Dendritic cells (DCs) play a critical role in orchestrating adaptive immune responses due to
their unique ability to initiate T cell responses and direct their differentiation into effector …

Rationale: The elderly experience profound systemic responses after stroke, which
contribute to higher mortality and more severe long-term disability. Recent studies have …

Group 3 innate lymphoid cells (ILC3s) regulate immunity and inflammation, yet their role in
cancer remains elusive. Here, we identify that colorectal cancer (CRC) manifests with …

The microbiota plays a fundamental role in the induction, education, and function of the host
immune system. In return, the host immune system has evolved multiple means by which to …