Colorectal cancer (CRC) is one of the commonest malignancies of Western countries, with
approximately half the incidence occurring in patients> 70 years of age. Elderly CRC …

As the therapeutic options for the treatment of colorectal cancer have expanded over the
past 20 years, so has the complexity of decision making. The goals of treatment in the …

Purpose Candidate predictive biomarkers for irinotecan and oxaliplatin were assessed in
1,628 patients in Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS), a large …

Purpose Uncertainty exists about whether elderly patients benefit to the same extent as
younger patients from combination therapy with irinotecan in the first-line treatment of …

Abstract Treatment of advanced colorectal cancer (CRC) increasingly requires a
multidisciplinary approach and multiple treatment options add to the complexity of clinical …

Abstract Learning Objectives After completing this course, the reader will be able to:
Evaluate elderly CRC patients with regard to overall health, independence, and …

As a result of an increasing life expectancy, the incidence of colon cancer in the older
population is rising. As a consequence oncologists and their older patients commonly face …

Background: The efficacy and safety of capecitabine and bevacizumab in elderly patients
with metastatic colorectal cancer (mCRC) considered unsuitable for receiving first-line …

Background In cancer patients with a large Body Surface Area, chemotherapy drug doses
are often reduced, as studies have suggested that their pharmacokinetics may be altered …

Metastatic colorectal cancer (CRC) represents an important health problem in which several
biological predictive and prognostic factors have been identified, including clinical features …