Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Exploiting bacterial DNA-acting enzymes and expanding their repertoire for genome
engineering have been major technological and conceptual advances in molecular biology …

Genome engineering technologies right from viral vector-mediated to protein-based editing—
which include zinc finger nucleases, TALENs, and CRISPR/Cas systems—have been …

Due to pioneering in vitro investigations on gene modification, gene engineering platforms
have incredibly improved to a safer and more powerful tool for the treatment of multiple …

Cpf1-linked base editors broaden the targeting scope of programmable cytidine deaminases
by recognizing thymidine-rich protospacer-adjacent motifs (PAM) without inducing DNA …

Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive neuromuscular disorder
most commonly caused by mutations disrupting the reading frame of the dystrophin (DMD) …

Beta (β)-thalassemia is one of the most significant hemoglobinopathy worldwide. The high
prevalence of the β-thalassemia carriers aggravates the disease burden for patients and …

The vast use of corticosteroids (CCSs) globally has led to an increase in CCS-induced
neuropsychiatric disorders (NPDs), a very common manifestation in patients after CCS …

Sažetak The rapid and exponential growth of genome editing has posed many challenges
for bioethics. This article briefly explains the nature of the technique and the particularly …

Abstract While CAR-T and tgTCR-T therapies have exhibited noteworthy and promising
outcomes in hematologic and solid tumors respectively, a set of distinct challenges remains …