Introduction Owing to limited efficient treatment strategies for highly prevalent and
distressing Parkinson's disease (PD), an impending need emerged for deciphering new …

Parkinson's disease (PD) is a common movement disorder associated with the degeneration
of dopaminergic neurons in the substantia nigra pars compacta. Mutations in the PD …

The integration of diverse chemical tools like small-molecule inhibitors, activity-based
probes (ABPs), and proteolysis targeting chimeras (PROTACs) advances clinical drug …

Autophagy is an intracellular recycling process that maintains cellular homeostasis by
degrading excess or defective macromolecules and organelles. Chaperone-mediated …

Parkinson's disease (PD) is a common neurodegenerative disease characterized by
progressive loss of dopaminergic neurons in the substantia nigra and the aggregation of …

Background COVID-19 is a complex, multi-system disease with varying severity and
symptoms. Identifying changes in critically ill COVID-19 patients' proteomes enables a better …

Amyotrophic Lateral Sclerosis (ALS) is a progressive disease with prevalent mitochondrial
dysfunctions affecting both upper and lower motor neurons in the motor cortex, brainstem …

Background Specific microglia responses are thought to contribute to the development and
progression of neurodegenerative diseases, including Parkinson's disease (PD). However …

Abstract In familial Parkinson's Disease (PD), which makes up 10-15% of all PD cases,
causative mutations in seventeen genes have been discovered. Study of these genes has …

The results in this thesis were developed in collaboration with Dr. Christian Grethe. This
thesis discusses and illustrates data from Dr. Christian Grethe to understand the process of …